Myopia – A 21st Century Public Health Issue

Based on the growing prevalence of myopia around the world, in particular in the young generations in East and Southeast Asia, it was the vision of the late Professor Brien Holden to initiate the International Myopia Institute. For long, Professor Holden, who already had founded and led the Brien Holden Vision Institute in Sydney, had realized the need to address the issues of myopia and myopia-related risks to vision, how clinicians could best manage myopia, and how further myopia research could be advanced.

Myopia needed to be recognized as a public health issue if there was to be a change in the approach to this condition, and only a collaborative effort across all eye care professions and researchers could bring this about. Under the auspices of the International Myopia Institute, experts from different myopia-related fields have come together, so that synergistic effects could develop and to make their latest research accessible and easy to understand for practitioners, governments, policy makers, educators, and the general public.

Starting with a World Health Organization (WHO)–associated global scientific meeting on myopia, which was held at the Brien Holden Vision Institute in Sydney, Australia in 2015, subgroups of researchers within The International Myopia Institute formed to address the major aspects of myopia. These include the public health issues of myopia, sequelae of myopia, such as the increased risks of sight-threatening complications due to glaucoma, retinal detachment, and myopic macular degeneration, the classification of myopia, prevention of myopia and its complications, and evidence for treatments.

With myopia projected to affect 50% of the world population by 2050 and the fear that myopia could become the most common cause of irreversible blindness worldwide,1 The International Myopia Institute, thus, is a collaborative effort to bring together individuals from across all areas of myopia research.

As a first major step, The International Myopia Institute has edited in this special IOVS issue a series of white papers on defining and classifying myopia, potential interventions, clinical trials and instrumentation, industry guidelines and ethical considerations, clinical management guidelines, experimental models of emmetropization and myopia, and the genetics of myopia. These articles, summarizing the current knowledge in the field and showing trends for future developments, may form a basis for further research, bridging gaps, and connecting people who so far had not intensively exchanged information and ideas. The IMI Myopia white paper reports initiative was chaired by Earl Smith and James Wolffsohn and facilitated by Monica Jong.

The future initiatives and role of The International Myopia Institute will be to foster these scientific cooperations, to be a platform for further harmonization of definitions and guide-lines, and also to promote the connections between the scientific world and the public, ultimately supporting the advocacy of this issue at the level of governments, peak health and regulating bodies.


Acknowledgments


Supported by the International Myopia Institute. The publication costs of the International Myopia Institute reports were supported by donations from the Brien Holden Vision Institute, Carl Zeiss Vision, CooperVision, Essilor, Alcon, and Vision Impact Institute.

Disclosure: S. Resnikoff, Brien Holden Vision Institute (C); J.B. Jonas,P;D. Friedman, None; M. He, None; M. Jong, None; J.J.Nichols, None; K. Ohno-Matsui, Novartis (F), Bayer (F), Santen (F), Senju (F); E.L. Smith III, Brien Holden Vision Institute (F), Tree House Eyes (C), SightGlass Vision (C), P; C.F. Wildsoet,P; H.R. Taylor, None; J.S. Wolffsohn, Alcon (F), Allergan (F), Aston EyeTech (F), Bausch & Lomb (F), BetterVision Ltd (F), Cooper-Vision (F, C), Eaglet Eye (F), European Union (F), Eyebag (F), EMPharma (F), EyeDocs (F), Gelflex (F), Innovate UK (F), Johnson & Johnson Vision Care (F, C, R), Lenstec (F), Medmont (F), Rayner (F), Tearlab (F), Th´ea (F), Optimec (F), Visioncare Research (F, C), Aston EyeTech (I), Atiya Vision (C), British Contact LensAssociation (C), University of Houston (C), Shire (C), Santen (C, R), RB (C), Santen (R), P; T.Y. Wong, Allergan (C), Bayer (C), Genentech (C), Novartis (C), Roche (C)


References

  1. Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology. 2016;123:1036–1042.
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COMMITTEES / WHITE PAPERS

Myopia Control Reports
Overview and Introduction



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Defining and Classifying Myopia



Prof. Ian Flitcroft (Leader)


Committee members:

  • Prof. Kyoko Ohno-Matsui
  • Prof. Lawrence Yannuzzi
  • Prof. Jost Jonas
  • Prof. Jugnoo Rahi
  • Prof. Serge Resnikoff
  • Dr. Monica Jong
  • Prof. Mingguang He
  • Prof. Kovin Naidoo
  • Dr. Susan Vitale
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Experimental Models of Emmetropizationand Myopia



Prof. Earl Smith and David Troilo (Leaders)


Committee Members:

  • Prof. David Troilo
  • Prof. Siegfried Wahl
  • Dr. Lisa Ostrin
  • Dr. Kee Chea-su
  • Dr. Tim Gawne
  • Dr. Andrei Tkatchenko
  • Prof. Machelle Pardue
  • Dr. Regan Ashby
  • Dr. Debora Nickla
  • Dr. Jody Summers
  • Dr. Falk Schroedl
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Myopia Genetics



Prof. Caroline Klaver (Leader)


Committee Members:

  • Dr. Virginie Verhoeven
  • Prof. Chris Hammond
  • Dr. Magda A. Meester-Smoor
  • Dr. Milly S. Tedja
  • Dr. Jaakko Kaprio
  • Dr. Annechien E.G. Haarman
  • Prof. David A. Mackey
  • Prof. Jeremy A. Guggenheim
  • CREAM Consortium
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Interventions for Myopia
Onset and Progression




Prof. Christine Wildsoet (Leader)


Committee members:

  • Dr. Klaus Trier
  • Prof. Seang Mei Saw
  • Prof. Padmaja Sankaridurg
  • Dr. Jeff Walline
  • Prof. Jez Guggenheim
  • Prof. Audrey Chia Wei Lin
  • Prof. Pei-Chang Wu
  • Dr. Scott Read
  • Dr. Pauline Cho
  • Dr. Jan Polling
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Clinical Myopia Control Trials
and Instrumentation Report



Prof. James Wolffsohn (Leader)


Committee members:

  • Dr. David Berntsen
  • Dr. Alexandra Benavente
  • Dr. Takohiro Hiraoka
  • Dr. Scott Read
  • Dr. David Atchison
  • Dr. Takashi Fujikado
  • Dr. Hetal Buckhurst
  • Dr. Pete Kolbaum
  • Dr. Arthur Bradley
  • Dr. Debbie Jones
  • Dr. Hidemasa Torii
  • Dr. Michael Collins
  • Dr. Nicola Logan
  • Dr. Linda Lundstrom
  • Masakazu Hirota
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Industry Guidelines and Ethical Considerations for Myopia Control



Prof. Lyndon Jones (Leader)


Committee members:

  • Dr. Fuen Vera-Diaz
  • Dr. Jacinto Santodomingo-Rubido
  • Dr. Timo Kratzer
  • Dr. Katrina Schmid
  • Prof. Jose Gonzales-Meijome
  • Dr. Stephanie Ramdass
  • Dr. Steve Newman
  • Prof. Jason Nichols
  • Dr. Bjorn Drobe
  • Dr. Lyle Gray
  • Prof. Donald Tan
  • Dr. Kah Ooi Tan
  • Dr. Arne Ohlendorf
  • Dr. Yee Ling Wong
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Clinical Management
Myopia Guidelines Report



Dr Kate Gifford (Leader)


Committee Members:

  • Dr. Langis Michaud
  • Dr. Tom Aller
  • Dr. Pauline Kang
  • Dr. Kathryn Richdale
  • Prof. Carly Lam
  • Mr. Jeroen Mulder
  • Dr. Dirk Seidel
  • Dr. Kathryn Saunders
  • Dr. Maria Liu
  • Dr. Willem Tideman
  • Dr. Janis Orr
  • Prof. Kathy Rose
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Harmonisation Committee



Prof. James Wolffsohn (Leader)


Committee Members:

  • Prof. Padmaja Sankaridurg
  • Prof. Serge Resnikoff
  • Prof. Earl L. Smith
  • Prof. Lyndon Jones
  • Prof. Kovin Naidoo
  • Dr. Kate Gifford
  • Dr. Monica Jong

IMI WHITE PAPER SESSION

Last November 2018 we hosted a very successful session at the American Academy of Optometry (AAO) in San Antonio, Texas, where we had the first preview of the long awaited white papers the IMI has been leading.

The session was attended by up to 400 people. The IMI brought together the following committee chairs, Professor Earl Smith (University of Houston), Professor Christine Wildsoet (UC Berkeley), Professor David Troilo (SUNY), Professor Ian Flitcroft (Mater Hospital, Dublin Institute of Technology), Professor James Wolffsohn (Aston University) and Dr Kate Gifford (Gerry & Johnson Optometrists, Queensland University of Technology); in a session that presented the key findings of the white papers and the implications for the eye care professions, followed by an in-depth panel discussion.